Biomarkers have many useful applications in cancer prevention and public health particularly in the monitoring of exposure to hazardous substances in identifying individuals at increased risk of dsease and in risk assessment at the population level. The iarc scientific publications aim to disseminate the results of iarc coordinated scientific research topics span the range of iarcs research scope and the series includes the cancer incidence in five continents volumes. This volume aims to provide a set of state of the art reviews of methodological issues in the use of biological markers in cancer epidemiology in addition it provides a brief expert statement of our present understanding of these issues under three broad headings study design and analysis development of biomarkers and application of . Biomarkers that would allow the identification of subjects exposed to carcinogenic agents or of individuals genetically susceptible to cancer would be of great value this volume is the product of an attempt to assess our current knowledge and experience with the use of biomarkers in cancer chemoprevention. O biomarker value in tissue sampled may not equal the value in the target tissue errors or omissions in the protocol o failure to specify the protocol in sufficient detail regarding timing and method of specimen
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